Body Protection Compound-157
Also Known AsBPC 157 · Bepecin · PL 14736 · PL-10
Synthetic pentadecapeptide derived from a protective protein isolated from human gastric juice (BPC). First described in the early 1990s by Predrag Sikiric at the University of Zagreb.
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-ValHow BPC-157 Works
Nitric Oxide System
BPC-157 modulates both constitutive (eNOS) and inducible (iNOS) nitric oxide synthase activity, influencing vasodilation, angiogenesis, and inflammatory signaling. Research shows it can counteract both NOS blockade (L-NAME) and NOS overstimulation (L-arginine).
Growth Factor Signaling
Upregulates VEGF, EGF, and their receptor expression in injury models, promoting angiogenesis and epithelial repair. Demonstrated effects on FAK-paxillin pathway activation.
Dopaminergic System
Interacts with the dopaminergic system, demonstrating protective effects against dopamine-depleting agents and modulating D1/D2 receptor activity in preclinical neurotoxicity models.
JAK-2/STAT-3 Pathway
Activates JAK-2/STAT-3 signaling cascade, contributing to its anti-inflammatory and tissue-protective effects across multiple organ systems.
Published Research
Gastrointestinal Protection
StrongExtensive preclinical evidence demonstrates protective and healing effects in various GI injury models including ethanol-induced ulcers, NSAID-induced lesions, inflammatory bowel disease models, and esophageal damage. BPC-157 promotes mucosal integrity, reduces inflammatory infiltration, and accelerates epithelial repair.
Tendon & Ligament Repair
StrongMultiple studies demonstrate accelerated healing in transected tendons (Achilles, quadriceps, patellar) in rat models. Mechanisms include increased fibroblast proliferation, collagen organization, and tendon-to-bone junction repair. Functional recovery metrics (grip strength, load-to-failure) consistently improve.
Muscle Injury Recovery
ModeratePreclinical data shows accelerated recovery from crush injuries, transection models, and denervation-induced atrophy. Effects attributed to enhanced angiogenesis, reduced inflammation, and improved neuromuscular junction recovery.
Neuroprotection
EmergingEmerging evidence for neuroprotective effects in cuprizone-induced demyelination, traumatic brain injury, and peripheral nerve injury models. Interaction with the dopaminergic system suggests potential relevance to Parkinson's-related research.
Bone Healing
PreclinicalPreclinical studies demonstrate accelerated fracture healing and improved callus formation. Effects on periosteal proliferation and osteogenic differentiation observed in segmental bone defect models.
Safety Profile
BPC-157 has demonstrated a wide safety margin in preclinical studies with no reported lethal dose (LD50 not established — no mortality observed even at extremely high doses in rodent models). No organ toxicity or mutagenicity has been reported in published literature. Human clinical trial data remains limited.
Handling & Storage
Reconstitute with bacteriostatic water. Direct gentle stream along vial wall — do not shake. Store reconstituted solution at 2-8°C and use within 30 days. Lyophilized powder stable at -20°C for 24+ months.
Peer-Reviewed Literature
- 1
Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract
Sikiric P, Seiwerth S, Rucman R, et al.
- 2
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
Chang CH, Tsai WC, Lin MS, et al.
- 3
Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications
Sikiric P, Seiwerth S, Rucman R, et al.
- 4
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
Gwyer D, Wragg NM, Wilson SL.
- 5
Rat inferior caval vein (ICV) ligature and particular pentadecapeptide BPC 157 therapy
Vukojevic J, Siroglavic M, Kasun M, et al.
BPC-157 FAQ
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide derived from a naturally occurring protective protein found in human gastric juice. It has been extensively studied in preclinical models for tissue repair, gastrointestinal protection, and anti-inflammatory properties.
What is the purity of G26x Peptides BPC-157?
Our BPC-157 is 99%+ purity, independently verified by Janoshik Analytical with a full Certificate of Analysis (COA) available for each batch. It is supplied as a lyophilized powder manufactured under GMP-adjacent conditions.
How should BPC-157 be stored?
Lyophilized BPC-157 should be stored at -20°C for long-term storage (stable for 24+ months). Once reconstituted with bacteriostatic water, store at 2-8°C (refrigerator) and use within 30 days.
What research has been published on BPC-157?
Over 100 peer-reviewed studies have been published on BPC-157, primarily from the laboratory of Predrag Sikiric at the University of Zagreb. Research areas include gastrointestinal mucosal protection, tendon and ligament healing, muscle injury recovery, neuroprotection, and bone healing. Most evidence comes from preclinical (animal) models.
Is BPC-157 the same as BPC-157 Acetate?
BPC-157 Acetate is a salt form that uses acetic acid during synthesis, resulting in slightly different solubility characteristics. The active peptide sequence is identical. The acetate form is sometimes preferred for nasal spray preparations due to its pH profile.
BPC-157 Products
All compounds 99%+ purity, verified by Janoshik Analytical. GMP-manufactured lyophilized powder.
BPC-157
10mgThe body's repair peptide — heals your gut, fixes injured tendons and joints, and accelerates recovery from virtually any tissue damage.
- Heals gut lining and fixes digestive issues
- Repairs tendons, ligaments, and joint injuries faster
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Disclaimer: This monograph is provided for educational and research purposes only. G26x Peptides products are sold exclusively as research chemicals. They are not intended for human consumption, therapeutic use, or as dietary supplements. All research should be conducted in compliance with applicable laws and institutional review board protocols. Information presented here is sourced from published peer-reviewed literature and does not constitute medical advice.